Advances in Protein Chemistry

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Front Cover 2
Advances in Protein Chemistry, Volume IV 5
Copyright Page 6
Contributers to Volume IV 7
Contents 9
Chapter 1. Protein Gels 13
- I. Introduction 14
- II. Gels with Long-Range Forces 17
- III. Formation and Properties of Network Gels 20
- IV. Gelatin 29
- V. Gels of Denatured Protein 59
- VI. Fibrin 63
- VII. Other Protein Gels 84
- References 86
Chapter 2. The Interactions of Proteins and Synthetic Detergents 91

Front Cover 2
Advances in Protein Chemistry, Volume IV 5
Copyright Page 6
Contributers to Volume IV 7
Contents 9
Chapter 1. Protein Gels 13
- I. Introduction 14
- II. Gels with Long-Range Forces 17
- III. Formation and Properties of Network Gels 20
- IV. Gelatin 29
- V. Gels of Denatured Protein 59
- VI. Fibrin 63
- VII. Other Protein Gels 84
- References 86
Chapter 2. The Interactions of Proteins and Synthetic Detergents 91
- I. Introduction 92
- II. Structure and State of Dispersion of the Synthetic Detergents . 92
- III. Quantitative Studies of the Interaction between Purified Proteins and Synthetic Detergents 95
- IV. Effects of Detergents in Biological Systems 112
- V. Mechanism of Interaction 118
- References 130
Chapter 3. Proteins of Pathogenic Bacteria 135
- I. Introduction 135
- II. General Methods 136
- III. Proteins of Hemolytic Streptococci, Group A 138
- IV. Classical Bacterial Exotoxins 147
- V. Extracellular Toxic Enzymes of Gram-Positive Bacteria 153
- VI. Proteins of Gram-Negative Bacteria 156
- VII. Concluding Remarks 158
- References 159
- Addendum 163
Chapter 4. The Plasma Proteins in Disease 167
- I. Introduction 168
- II. Principal Methods of Fractionation, Their Limitations, and General Implications 169
- III. Results of Plasma Protein Fractionation in Specific Diseases 192
- IV. Significance of Abnormalities in Plasma Protein Patterns 233
- V. Concluding Remarks 250
- References 252
Chapter 5. Preparative Electrophoresis and Ionophoresis 263
- I. Introduction 263
- II. Compartment Types of Apparatus 264
- III. Moving Boundary Apparatus 289
- References 304
Chapter 6. Stereochemistry of Amino Acids 309
- I. Introduction 310
- II. Configuration of Amino Acids 312
- III. Reactions of Amino Acids Involving Substitutions on the α-Carbon Atom 339
- IV. Catalytic Racemization 351
- V. Occurrence of D-Amino Acids and Their Derivatives in Nature 374
- References 388
Chapter 7. X-Ray Studies of Amino Acids and Peptides 397
- I. Introduction 397
- II. X-Ray Investigations 399
- III. Crystal Structures of Amino Acids and Peptides 400
- IV. Structure of Proteins 410
- References 418
Chapter 8. Heme Proteins 419
- I. Introduction 422
- II. Porphyrins 423
- III. Heme Proteins 428
- IV. Size and Shape of Heme Proteins 442
- V. Linked Functions 448
- VI. Oxygen Equilibria 455
- VII. Bohr Effect on Oxygen Equilibria and Identification of Oxygen Linked Acid Groups 470
- VIII. Identification of the Oxygen-Linked Acid Groups in Horse Hemoglobin 476
- IX. The Heat of Oxygenation of Hemoglobin 479
- X. Equilibrium Involving Oxygen and Carbon Monoxide and Heme Proteins 483
- XI. Velocity of Reactions with Oxygen and Carbon Monoxide 488
- XII. Physiological Implications of the Bohr Effect 494
- XIII. Carbamino Compounds 497
- XIV. Magnetic Properties of Hemoglobin 508
- XV. Oxidation-Reduction Phenomena 521
- XVI. The Heme-Protein Linkage in Cytochrome c, Peroxidase and Catalase 529
- XVII. Other Reactions of Heme Proteins 533
- XVIII. Conclusions 536
- References 537
Author Index 545
Subject Index 570

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