Molecular Genetic Medicine, Volume III, summarizes progress in several of the most important areas of modern molecular genetics and medicine.
The book opens with a chapter on the birth and early development of the field of human gene therapy and the earliest conceptual and technical descriptions of the issues and opportunities in this new area of medicine. This is followed by separate chapters on the gene responsible for cystic fibrosis; interactions and genetic phenomena that accompany the progression of astrocytic tumors; and molecular biology of Alzheimer’s disease; and the search for the Huntington's disease gene and the role of genetic instability in this disease.
The final chapter discusses the ways in which both the medical insurance and genetics industries will have to respond to changes in the power of genetic information and its ability to predict coronary vascular disease, cancer, neurological disease, and all the other common afflictions that constitute the bulk of their businesses.

• Front Cover 2
• Molecular Genetic Medicine 5
• Copyright Page 6
• Table of Contents 7
• Contributors 11
• Preface 13
• Chapter 1. Milestones and Events in the Early Development of Human Gene Therapy 17
  • I. Phase 1. Prior to 1970: Genetically Marked Cells and DNA-Mediated Transformation 19
  • II. Phase 2. The Cline Experiment, Efficient Vectors, in Vitro Models, and the Maturing Ethical and Public Policy Debate 26
  • III. Phase 3. The Regulatory Process and the First Direct Clinical Applications: The Recombinant Advisory Committee (RAC), Its G 34
  • Acknowledgment 41
  • References 41
• Chapter 2. Molecular Biology of Cystic Fibrosis 49
  • I. Introduction and History 49
  • II. Identification of the CF Gene 50