Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.

Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.

• METABOLIC SYNDROME AND NEUROLOGICAL DISORDERS 4
• CONTENTS 10
• FOREWORD 14
• PREFACE 16
• ACKNOWLEDGMENTS 18
• CONTRIBUTORS 20
• 1 INSULIN RESISTANCE AND METABOLIC FAILURE UNDERLIE ALZHEIMER DISEASE 24
  • 1.1 INTRODUCTION 25
  • 1.2 MEDIATORS OF INSULIN SIGNALING 25
    • 1.2.1 Insulin, the Master Hormone 25
    • 1.2.6 Cross Talk between Insulin/IGF and Other Major Signal Transduction Networks in the Brain 26
    • 1.2.4 Insulin and IGF Signaling in the Brain 26
    • 1.2.2 Insulin-Stimulated Effects 26
    • 1.2.5 Insulin and IGF Signal Transduction: Steps in Pathway Activation 26
    • 1.2.3 Insulin-Like Growth Factors (IGFs) 26