Spis treści Front Cover 2 Advances in Protein Chemistry, Volume IV 5 Copyright Page 6 Contributers to Volume IV 7 Contents 9 Chapter 1. Protein Gels 13 I. Introduction 14 II. Gels with Long-Range Forces 17 III. Formation and Properties of Network Gels 20 IV. Gelatin 29 V. Gels of Denatured Protein 59 VI. Fibrin 63 VII. Other Protein Gels 84 References 86 Chapter 2. The Interactions of Proteins and Synthetic Detergents 91 Front Cover 2 Advances in Protein Chemistry, Volume IV 5 Copyright Page 6 Contributers to Volume IV 7 Contents 9 Chapter 1. Protein Gels 13 I. Introduction 14 II. Gels with Long-Range Forces 17 III. Formation and Properties of Network Gels 20 IV. Gelatin 29 V. Gels of Denatured Protein 59 VI. Fibrin 63 VII. Other Protein Gels 84 References 86 Chapter 2. The Interactions of Proteins and Synthetic Detergents 91 II. Structure and State of Dispersion of the Synthetic Detergents . 92 I. Introduction 92 III. Quantitative Studies of the Interaction between Purified Proteins and Synthetic Detergents 95 IV. Effects of Detergents in Biological Systems 112 V. Mechanism of Interaction 118 References 130 Chapter 3. Proteins of Pathogenic Bacteria 135 I. Introduction 135 II. General Methods 136 III. Proteins of Hemolytic Streptococci, Group A 138 IV. Classical Bacterial Exotoxins 147 V. Extracellular Toxic Enzymes of Gram-Positive Bacteria 153 VI. Proteins of Gram-Negative Bacteria 156 VII. Concluding Remarks 158 References 159 Addendum 163 Chapter 4. The Plasma Proteins in Disease 167 I. Introduction 168 II. Principal Methods of Fractionation, Their Limitations, and General Implications 169 III. Results of Plasma Protein Fractionation in Specific Diseases 192 IV. Significance of Abnormalities in Plasma Protein Patterns 233 V. Concluding Remarks 250 References 252 Chapter 5. Preparative Electrophoresis and Ionophoresis 263 I. Introduction 263 II. Compartment Types of Apparatus 264 III. Moving Boundary Apparatus 289 References 304 Chapter 6. Stereochemistry of Amino Acids 309 I. Introduction 310 II. Configuration of Amino Acids 312 III. Reactions of Amino Acids Involving Substitutions on the α-Carbon Atom 339 IV. Catalytic Racemization 351 V. Occurrence of D-Amino Acids and Their Derivatives in Nature 374 References 388 Chapter 7. X-Ray Studies of Amino Acids and Peptides 397 I. Introduction 397 II. X-Ray Investigations 399 III. Crystal Structures of Amino Acids and Peptides 400 IV. Structure of Proteins 410 References 418 Chapter 8. Heme Proteins 419 I. Introduction 422 II. Porphyrins 423 III. Heme Proteins 428 IV. Size and Shape of Heme Proteins 442 V. Linked Functions 448 VI. Oxygen Equilibria 455 VII. Bohr Effect on Oxygen Equilibria and Identification of Oxygen Linked Acid Groups 470 VIII. Identification of the Oxygen-Linked Acid Groups in Horse Hemoglobin 476 IX. The Heat of Oxygenation of Hemoglobin 479 X. Equilibrium Involving Oxygen and Carbon Monoxide and Heme Proteins 483 XI. Velocity of Reactions with Oxygen and Carbon Monoxide 488 XII. Physiological Implications of the Bohr Effect 494 XIII. Carbamino Compounds 497 XIV. Magnetic Properties of Hemoglobin 508 XV. Oxidation-Reduction Phenomena 521 XVI. The Heme-Protein Linkage in Cytochrome c, Peroxidase and Catalase 529 XVII. Other Reactions of Heme Proteins 533 XVIII. Conclusions 536 References 537 Author Index 545 Subject Index 570 Pokaż więcej