TOC Front Cover 2 Advances in Applied Microbiology, Volume 1 5 Copyright Page 6 Contributors 7 Preface 9 Contents 11 Chapter 1. Protected Fermentation 15 I. Introduction 15 II. Problems of Sterility Testing in Fermentation Processes 16 III. Classification of Fermentation Processes According to the Importance of Contamination 19 IV. Sources of Contamination in Aseptic Fermentation Processes 21 V. Application of Antimicrobial Agents for the Protection of Fermentation Processes 22 VI. Biosynthesis of Chlortetracycline without Maintenance of Aseptic Conditions 26 VII. Perspectives 27 VIII. Conclusions and Summary 31 Front Cover 2 Advances in Applied Microbiology, Volume 1 5 Copyright Page 6 Contributors 7 Preface 9 Contents 11 Chapter 1. Protected Fermentation 15 I. Introduction 15 II. Problems of Sterility Testing in Fermentation Processes 16 III. Classification of Fermentation Processes According to the Importance of Contamination 19 IV. Sources of Contamination in Aseptic Fermentation Processes 21 V. Application of Antimicrobial Agents for the Protection of Fermentation Processes 22 VI. Biosynthesis of Chlortetracycline without Maintenance of Aseptic Conditions 26 VII. Perspectives 27 VIII. Conclusions and Summary 31 References 32 Chapter 2. The Mechanism of Penicillin Biosynthesis 37 I. Introduction 37 II. Precursors of the Side Chain 39 III. Precursors of the β-Lactam-Thiazolidine Ring Nucleus 40 IV. Condensation of the Precursor Moieties 52 V. Future Experimentation 57 VI. Summary 58 References 59 Chapter 3. Preservation of Foods and Drugs by Ionizing Radiations 63 I. Introduction and Scope 63 II. History 64 III. Nature of High-Energy Radiation 64 IV. Sources of High-Energy Radiation 65 V. Dosimetry 68 VI. Physical and Chemical Changes 68 VII. Microbiological Effects 74 VIII. Wholesomeness 77 IX. Applications 79 X. Containers 81 XI. Economic Considerations 82 XII. Summary and Conclusions 83 References 84 Chapter 4. The Status of Antibiotics in Plant Disease Control 89 I. Introduction 89 II. Selective Toxicity 90 III. Absorption and Translocation 91 IV. Mode of Action 95 V. Summary 96 References 97 Chapter 5. Microbial Synthesis of Cobamides 101 I. Introduction 101 II. Analytical Methods for the Determination of Cobamides 106 III. Microbial Processes for Synthesis of Naturally Occurring Cobamides 111 IV. Microbial Synthsis of “Unnatural Cobamides” 120 References 126 Chaptet 6. Factors Affecting the Antimicrobial Activity of Phenols 137 I. Introduction 137 II. The Effect of Temperature 138 III. The Effect of Oxygen Tension 139 IV. The Effect of pH 140 V. The Effect of Extraneous Materials 140 VI. The Effect of the Size of the Bacterial Population 145 VII. The Revival of Bacteria After Treatment with Phenol 146 VIII. The Development of Resistance to Phenols 147 X. The Use of Phenols with Other Inhibitors 150 References 151 Chapter 7. Germfree Animal Techniques and Their Applications 155 I. Introduction 155 II. Methods and Equipment 156 III. Characteristics of Germfree Animals 162 IV. Applications of Germfree Animals 167 V. Additional Research Needs 181 VI. Summary 185 References 185 Chapter 8. Insect Microbiology 189 I. Introduction 189 II. Bacterial Diseases 190 III. Fungous Diseases 193 IV. Protozoan Diseases 195 V. Rickettsia1 Diseases 199 VI. Virus Diseases 202 VII. Nematode Diseases 207 References 212 VIII. Summary and Conclusions 212 Chapter 9. The Production of Amino Acids by Fermentation Processes 215 I. Introduction 215 II. Possibility of Amino Acid Production by Various Microorganisms 216 III. Glutamic Acid Fermentation 217 IV. Lysine Fermentation 222 V. Ornithine Fermentation 224 VI. Miscellaneous Amino Acid Fermentations 225 References 226 Chapter 10. Continuous Industrial Fermentations 229 I. Introduction 229 II. Classification of Continuous Operations and Processes 231 III. Summary, Predictions, and Experimental Tests of Continuous Fermentation Theory 233 IV. Continuous Fermentation in Practice 251 References 269 Chapter 11. The Large-Scale Growth of Higher Fungi 275 I. Introduction 275 II. History of Mushroom Culture 277 III. Research in the Mushroom Industry 279 IV. Development of Deep-Vat Fermentation Methods 283 V. Food Yeasts and Molds in Submerged Culture 283 VI. Mushrooms in Submerged Culture 284 VII. Problems to be Met in the Large-Scale Production of Higher Fungi in Submerged Culture 289 References 291 Author Index 293 Subject Index 314 Show more