Advances in Genetics

Description

Advances in Genetics, Volume 97 provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. New chapters in this recent release include Plant photomorphogenesis, TBC, and Exosome/EV Biomolecule Delivery "transfer". Users will find a series that continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

Critically analyzes future directions for the study of clinical genetics
Written and edited by recognized leaders in the field
Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics

Front Cover 2
Advances in Genetics 3
ADVANCES IN GENETICS, VOLUME 97 4
Advances in GeneticsEdited byTheodore FriedmannDepartment of Pediatrics, University of California at San Diego,School of Me ... 5
Advances in GeneticsEdited byTheodore FriedmannDepartment of Pediatrics, University of California at San Diego,School of Me ... 5
Contents 7
CONTRIBUTORS 9
One - Sixteen Years of Meiotic Silencing by Unpaired DNA 11
- 1. INTRODUCTION 12
- 2. THE DISCOVERY OF MEIOTIC SILENCING BY UNPAIRED DNA 13
  - 2.1 Asm-1, a Conserved Regulator of Fungal Development 13
  - 2.2 Mating in Neurospora crassa 14
  - 2.3 Ascus Dominance and Gene Pairing During Meiosis 15
  - 2.4 Meiotic Silencing by Unpaired DNA 19

Front Cover 2
Advances in Genetics 3
ADVANCES IN GENETICS, VOLUME 97 4
Advances in GeneticsEdited byTheodore FriedmannDepartment of Pediatrics, University of California at San Diego,School of Me ... 5
Advances in GeneticsEdited byTheodore FriedmannDepartment of Pediatrics, University of California at San Diego,School of Me ... 5
Contents 7
CONTRIBUTORS 9
One - Sixteen Years of Meiotic Silencing by Unpaired DNA 11
- 1. INTRODUCTION 12
- 2. THE DISCOVERY OF MEIOTIC SILENCING BY UNPAIRED DNA 13
  - 2.1 Asm-1, a Conserved Regulator of Fungal Development 13
  - 2.2 Mating in Neurospora crassa 14
  - 2.3 Ascus Dominance and Gene Pairing During Meiosis 15
  - 2.4 Meiotic Silencing by Unpaired DNA 19
- 3. GENETIC ANALYSIS OF THE UNPAIRED DNA DETECTION MECHANISM OF MEIOTIC SILENCING BY UNPAIRED DNA 20
  - 3.1 Properties of Unpaired DNA Required for Silencing 20
  - 3.2 Meiotic Silencing by Unpaired DNA Silencing Does Not Spread Between Asci or Genes 21
  - 3.3 DNA Methylation Interferes With the Identification of Pairing Partners 26
  - 3.4 The Search for Pairing Partners Is Spatially Constrained 28
- 4. RNA SILENCING AND MEIOTIC SILENCING BY UNPAIRED DNA PROTEINS 31
  - 4.1 Silencing the Silencer 31
  - 4.2 Meiotic Silencing by Unpaired DNA Is a Small RNA–Based Silencing Pathway 34
  - 4.3 Identification and Characterization of Other Meiotic Silencing by Unpaired DNA Proteins 37
  - 4.4 A Silencing Complex Stands Guard Around the Nucleus During Meiosis 41
  - 4.5 A Model for Meiotic Silencing by Unpaired DNA 42
- 5. MEIOTIC SILENCING BY UNPAIRED DNA IN THE WILD 45
- 6. THE PURPOSE OF MEIOTIC SILENCING BY UNPAIRED DNA 46
- 7. CONCLUSION 48
- REFERENCES 49
Two - Sleeping Beauty? Developmental Timing, Sleep, and the Circadian Clock in Caenorhabditis elegans 53
- 1. INTRODUCTION 54
- 2. CIRCADIAN CLOCKS AND THE CAENORHABDITIS ELEGANS DEVELOPMENTAL TIMER 55
  - 2.1 Postembryonic Development in Caenorhabditis elegans 55
  - 2.2 How Does a Biological Clock Look? 58
  - 2.3 The Mechanism of the Circadian Clock 59
  - 2.4 A Clock Gene Homolog and Its Role in Postembryonic Development 61
  - 2.5 New Methods to Study Larval Development in Single Animals 64
- 3. SLEEP 64
  - 3.1 Caenorhabditis elegans Sleeplike Behavior 68
  - 3.2 Neural Activity During Caenorhabditis elegans Lethargus 69
  - 3.3 Neuromodulators and Molecular Pathways Regulating Caenorhabditis elegans Lethargus 71
- 4. SYNTHESIS 75
  - 4.1 Using Lethargus to Learn About Sleep (and Vice Versa) 75
    - 4.1.1 Applying the Two-Process Model to Worms 75
    - 4.1.3 On the Level of Circuits and Molecules 76
    - 4.1.2 Linking the Function of Sleep to Mechanisms 76
  - 4.2 Using the Circadian Clock to Learn About Developmental Timing (and Vice Versa) 77
    - 4.2.1 What Is the Same and What Is Different? 77
    - 4.2.2 The Molecular Mechanism of Biological Oscillators 78
    - 4.2.4 Iterating Between Models 79
    - 4.2.3 Outputs of Oscillators 79
  - ACKNOWLEDGMENTS 81
  - REFERENCES 82
- Three - Integrated Genomic Medicine: A Paradigm for Rare Diseases and Beyond 91
  - 1. INTRODUCTION 92
    - 1.2 Individualized Medicine 93
    - 1.1 Stratified Medicine 93
    - 1.3 Individual Patient–Oriented Research 99
  - 2. INTEGRATED GENOMIC MEDICINE SCIENTIFIC STRATEGIES 100
    - 2.1 Molecular and Genomic Profiling 100
    - 2.2 Pathogenic Lesion Identification via Bioinformatics Analysis 102
    - 2.3 Pathophysiologic Assessment and Functional Verification 104
      - 2.3.1 In Vivo Pathophysiological Studies 105
      - 2.3.2 Induced Pluripotent Stem Cells 105
      - 2.3.3 Model Organism “Avatars” 106
      - 2.3.4 In Silico Modeling and Simulation Studies 107
    - 2.4 Therapeutic Choice 107
    - 2.5 Phenotypic Monitoring for Clinical Studies 108
    - 2.6 Clinical Trial Design 109
    - 2.7 Data Dissemination and Query Capabilities 110
  - 3. INFRASTRUCTURE AND RESOURCES 111
    - 3.2 Training Programs 111
    - 3.1 Establishing Research Teams 111
    - 3.3 Databases and Delivery Systems 112
  - 4. DISCUSSION 112
  - ACKNOWLEDGMENTS 114
  - REFERENCES 114
- Back Cover 125

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