Regulation of matrix Accumulation

Opis

Regulation of Matrix Accumulation discusses the development of research and studies on connective tissue.
This book emphasizes biochemical characterization of individual connective tissue components and interactions between cells and extracellular macromolecules. Other topics include the intracellular turnover of collagen; biological regulation of collagenase activity; feedback regulation of collagen synthesis; steroid hormone regulation of extracellular matrix proteins; and control of elastin synthesis, including its molecular and cellular aspects. The catalytic and biological properties of elastases; characterization and regulation of lysyl oxidase; and matrix accumulation and the development of form, considering proteoglycans and branching morphogenesis, are explained as well. Included in this text is an autobiography and personal retrospective by Miles Partridge, one of the contributors that greatly influenced the progress in understanding extracellular matrix biology.
This publication is a good reference for students and researchers conducting work on biology, specifically on connective tissue.

Spis treści

Front Cover 2
Regulation of Matrix Accumulation 5
Copyright Page 6
Table of Contents 7
CONTRIBUTORS 11
PREFACE 13
REFLECTIONS ON A CAREER IN CONNECTIVE TISSUE RESEARCH 17
- Text 17
- References 43
CHAPTER 1. INTRACELLULAR TURNOVER OF COLLAGEN 45
- I. Introduction 45
- II. Biosynthesis 46
- III. Proteolytic Processing of Secretory Proteins 50
- IV. Role of Intracellular Proteinases in Maintaining Collagen Synthesis 51
- V. Degradation of Secretory Proteins: Collagen 52

Front Cover 2
Regulation of Matrix Accumulation 5
Copyright Page 6
Table of Contents 7
CONTRIBUTORS 11
PREFACE 13
REFLECTIONS ON A CAREER IN CONNECTIVE TISSUE RESEARCH 17
- Text 17
- References 43
CHAPTER 1. INTRACELLULAR TURNOVER OF COLLAGEN 45
- I. Introduction 45
- II. Biosynthesis 46
- III. Proteolytic Processing of Secretory Proteins 50
- IV. Role of Intracellular Proteinases in Maintaining Collagen Synthesis 51
- V. Degradation of Secretory Proteins: Collagen 52
- VI. Regulation of Collagen Production by Changes in Intracellular Degradation 62
- References 64
CHAPTER 2. THE BIOLOGICAL REGULATION OF COLLAGENASE ACTIVITY 69
- I. Introduction 69
- II. Regulatory Aspects of Molecules Intrinsic to the Collagenolytic System 73
- III. Extrinsic Regulation of Collagenase Activity: A Selective Survey of Collagenolytic Systems and Their Regulation 94
- IV. Summary and Future Perspective 106
- References 108
CHAPTER 3. FEEDBACK REGULATION OF COLLAGEN SYNTHESIS 115
- I. Introduction 116
- II. The Aminopropeptides 119
- III. Experiments on Feedback Inhibition of Aminopropeptides on Collagen Biosynthesis 123
- IV. Clinical Importance of Collagen Feedback Regulation 129
- References 131
CHAPTER 4. STEROID HORMONE REGULATION OF EXTRACELLULAR MATRIX PROTEINS 135
- I. Introduction 136
- II. Glucocorticoid Regulation of Collagen Metabolism in Tissues 137
- III. Glucocorticoid Regulation of Collagen Metabolism in Cells 158
- IV. Sex Hormone Regulation of Collagen Metabolism in Tissues 166
- V. Sex Hormone Regulation of Collagen Metabolism in Cells 171
- VI. Glucocorticoid Regulation of Elastin Metabolism in Tissues 172
- VII. Glucocorticoid Regulation of Elastin Metabolism in Cells 174
- VIII. Sex Hormone Regulation of Elastin Metabolism in Vascular Tissue 175
- IX. Steroid Hormone Regulation of Fibronectin Metabolism in Liver and Cells 176
- X. Future Prospectives of Steroid Hormone Regulation of the Synthesis of the Proteinaceous Components of the Extracellular Matri 179
- References 183
CHAPTER 5. CONTROL OF ELASTIN SYNTHESIS: MOLECULAR AND CELLULAR ASPECTS 193
- I. Introduction 194
- II. Molecular Biology 199
- III. Biosynthesis and Secretion 206
- IV. Assembly of Elastic Fibers 210
- V. Regulation of Production 211
- VI. Evolution of Elastin 224
- VII. Summary and Perspectives 226
- References 226
CHAPTER 6. ELASTASES: CATALYTIC AND BIOLOGICAL PROPERTIES 233
- I. Introduction 234
- II. Definition and Occurrence 235
- III. Pancreatic Elastases: Occurrence and Molecular Properties 236
- IV. Leukocyte Elastases: Occurrence and Molecular Properties 241
- V. Catalytic Properties of Pancreatic and Leukocyte Elastases 245
- VI. Pancreatic and Leukocyte Elastase Inhibitors 264
- VII. Other Mammalian Elastases 284
- VIII. Nonmammalian Elastases 287
- IX. Assay of Elastases: A Critical Minireview 292
- X. Pathological Role of Elastases 302
- XI. Elastase Inhibitors as Potential Drugs 318
- XII. Concluding Remarks 321
- References 322
CHAPTER 7. CHARACTERIZATION AND REGULATION OF LYSYL OXIDASE 337
- I. Introduction 338
- II. Posttranslational Modifications of Connective Tissue Proteins 339
- III. Assay and Purification of Lysyl Oxidase 347
- IV. Physical Properties 352
- V. Catalytic Properties 363
- VI. Pathology 384
- VII. Physiological Control of Lysyl Oxidase 394
- VIII. Summary and Prospects 404
- References 405
CHAPTER 8. MATRIX ACCUMULATION AND THE DEVELOPMENT OF FORM: PROTEOGLYCANS AND BRANCHING MORPHOGENESIS 415
- I. Introduction 416
- II. Branching Morphogenesis 416
- III. Proteoglycans and Hyaluronic Acid 426
- IV. Proteoglycans and Hyaluronate in Branching Organs 435
- V. Effects of β-D-Xyloside 439
- VI. Basal Lamina in Branching Morphogenesis 445
- VII. Possible Functions of Proteoglycans in Branching Morphogenesis 451
- References 456
INDEX 461

Pokaż więcej

Opis

Spis treści

Recenzje (0)