Salivary Gland Neoplasms

Opis

This volume in the book series 'Advances in Oto-Rhino-Laryngology' summarizes the current scientific knowledge of salivary gland neoplasms and illustrates recent advances in this clinical area. Chapters are authored by world renowned experts who cover the full breadth of salivary gland neoplasms, from benign to malignant, primary to secondary, and pediatric to adult. This comprehensive review highlights the outcome of treatments as well as the classification, diagnosis, and management of salivary gland neoplasms. It also includes commentary on the future perspective necessary for improvement. All clinicians, both surgical and non-surgical, involved in the diagnosis and treatment of patients with symptoms and diseases of the salivary gland, will find this book indispensable reading. It is also a beneficial educational resource for clinicians, students, and experts in the field.

Spis treści

Cover 2
Front Matter 5
Contents 7
Preface 9
Classification of Salivary Gland Neoplasms 11
- Abstract 11
- Introduction 11
- History of Pathological Classification 12
- Clinician Stakeholders 14
- Histopathological Grading Classification 15
- Histotyping Classification 15
- Molecular Biology and Genetic Classification 16
- Conclusion 17
- References 17
- TNM Stage Classification 17

Cover 2
Front Matter 5
Contents 7
Preface 9
Classification of Salivary Gland Neoplasms 11
- Abstract 11
- Introduction 11
- History of Pathological Classification 12
- Clinician Stakeholders 14
- Histopathological Grading Classification 15
- Histotyping Classification 15
- Molecular Biology and Genetic Classification 16
- Conclusion 17
- References 17
- TNM Stage Classification 17
Frequency and Histopathology by Site, Major Pathologies, Symptoms and Signs of Salivary Gland Neoplasms 19
- Abstract 19
- Introduction 19
- Salivary Gland Neoplasms in Children 22
- Clinical Summary of the Common Salivary Pathologies (table 1) 22
- Symptoms and Signs 24
Molecular Pathology and Biomarkers 27
- Abstract 27
- Introduction 27
- Mucoepidermoid Carcinoma 28
- Adenoid Cystic Carcinoma 29
- Salivary Duct Carcinoma 30
- Mammary Analog Secretory Carcinoma 30
- Carcinoma Ex-Pleomorphic Adenoma 31
- Hyalinizing Clear Cell Carcinoma 31
- Pleomorphic Adenoma 31
- Conclusion 32
- References 32
- Polymorphous Low-Grade Adenocarcinomaand Cribriform Adenocarcinoma of MinorSalivary Glands 32
Evaluation: Imaging Studies 35
- Abstract 35
- Conventional Imaging 35
- Tumor Staging 37
- Perineural Spread 37
- Posttreatment Surveillance 38
- Advanced Imaging Techniques 39
- Imaging of Selected Salivary Gland Masses 43
- Conclusion 46
- References 46
Evaluation: Fine Needle Aspiration Cytology,Ultrasound-Guided Core Biopsy and Open BiopsyTechniques 49
- Abstract 49
- Introduction 49
- The Use of Fine Needle Aspiration Cytology 50
- Reliance on Fine Needle Aspiration Cytology Alone 50
- Biopsy Assessment of Pathology Pre-Operatively 50
- The Need for More than Cells for Diagnosis 51
- An Alternative: Ultrasound-Guided CoreBiopsy 51
- Controversies over the Use of Ultrasound-Guided Core Biopsy 52
- The Evidence for Ultrasound-Guided CoreBiopsy 52
- References 54
- Intra-Operative Frozen Sections 54
- Conclusion 54
Facial Nerve Monitoring 56
- Abstract 56
- Introduction 56
- Systems for Facial Nerve Monitoring 57
- Electrophysiology and the Basis of Facial Nerve Monitoring 57
- Indications 58
- Benefits 59
- Pitfalls and Limitations 60
- Conclusion 61
- References 61
- Nerve Monitoring in Litigations Involving Parotid Surgery 61
Surgery for Benign Salivary Neoplasms 63
- Abstract 63
- Minor Salivary Gland 63
- Sublingual Salivary Gland 65
- Submandibular Gland 67
- Parotid Gland 68
- Extracapsular Dissection 69
- References 71
Recurrent Benign Salivary Gland Neoplasms 73
- Abstract 73
- Recurrent Pleomorphic Adenoma 73
- Metachronous Warthin Tumor 78
- Other Recurrent Benign Salivary Neoplasms 78
- Carcinoma Ex-Pleomorphic Adenoma 78
- Recurrent Benign Salivary Neoplasms of the Submandibular Gland and Minor SalivaryGlands 79
- Conclusions 79
- References 79
Prognostic Scoring for Malignant Salivary Gland Neoplasms 81
- Abstract 81
- Introduction 81
- Univariate and Multivariate Survival Analyses for Patients with Parotid Carcinoma 82
- General Issues: Prognostic Research Relates Oncological Outcomes to Specific Prognostic Factors 82
- Prognostic Research Echelons in Salivary Gland Carcinoma, with Increasing Complexity Paralleling Increasing Clinical Usefulness 82
- One Step Further: Creation of a SummaryIndex, Score or Nomogram 83
- The Last Step on the Prognostic Ladder:External Validation 87
- User-Friendly Translation for Use in the Clinic 90
- Limitations of the Current Prognostic IndexSystem and Future Developments 90
- References 91
- Future Developments in Prognostic Research 91
Surgery for Primary Malignant Parotid Neoplasms 93
- Abstract 93
- Introduction 93
- Evaluation 94
- Presentation 94
- Surgical Treatment 95
- Surgical Management of the Neck 100
- Management of the Facial Nerve 100
- Conclusions 102
- References 102
- Efficacy of Treatment 102
Metastatic Cancer to the Parotid 105
- Abstract 105
- Advances in the Management of Metastatic Cutaneous Squamous Cell Carcinoma of theParotid Gland 105
- Advances in the Management of Melanoma Metastatic to the Parotid Gland 108
- References 111
Surgery for Malignant Submandibular Gland Neoplasms 114
- Abstract 114
- Introduction 114
- Imaging Studies 115
- Clinical Presentation 115
- Adenoid Cystic Carcinoma 117
- Fine-Needle Aspiration Biopsy 117
- Histopathology 117
- Adenocarcinoma 118
- Treatment 118
- Mucoepidermoid Carcinoma 118
- Surgical Technique for Excision of Malignant Submandibular Gland Tumors 119
- Surgical Management of the Neck 121
- Conclusions 121
- References 121
Surgery for Malignant Sublingual and Minor Salivary Gland Neoplasms 123
- Malignant Sublingual Gland Neoplasms 123
- Abstract 123
- Malignant Minor Salivary Gland Neoplasms 124
- References 128
Facial Reconstruction and Rehabilitation 130
- Abstract 130
- Introduction 130
- Preoperative Assessment 131
- Evaluation of Facial Nonmotor Function 132
- Evaluation of Facial Motor Function 132
- Selection of an Individualized Facial Rehabilitation Treatment Plan 133
- Surgical Rehabilitation 133
- Nonsurgical Rehabilitation 138
- Conclusion 138
- References 139
Management of Regional Metastases of Malignant Salivary Gland Neoplasms 142
- Introduction 142
- Abstract 142
- The Clinically Positive Neck 143
- The Clinically Negative Neck 144
- Sentinel Node Biopsy in Primary Parotid Cancer 147
- Conclusion 148
- References 149
Indications for Salivary Gland Radiotherapy 151
- Radiotherapy for Benign Disease 151
- Abstract 151
- Radiotherapy for Malignant Disease 153
- References 156
Chemotherapy and Targeted Therapy 158
- Abstract 158
- Introduction 158
- Recurrent and/or Metastatic Salivary Gland Carcinomas 159
- Single-Agent Chemotherapy 159
- Combined-Agent Chemotherapy 160
- Molecular Targeted Treatments 162
- Conclusions 164
- Hormonal Treatment 164
- References 165
Management of Inoperable Malignant Neoplasms 167
- Abstract 167
- Introduction 167
- Patterns of Disease 168
- Clinical Manifestations and Patient Evaluation 168
- Conventional Photon Radiation 169
- Neutron and Carbon Ion Radiation 170
- Proton Radiation 172
- Hyperfractionated Photon Radiation 173
- Concurrent Chemoradiation 173
- Hypofractionated Stereotactic PhotonRadiation 173
- Palliation 174
- Techniques of Radiation 174
- Conclusions 175
- References 175
- Treatment Follow-Up 175
Management of Recurrent Malignant Salivary Neoplasms 178
- Abstract 178
- Introduction 178
- Follow-Up of Primary Tumors 179
- Management of Recurrent Salivary Gland Tumors 179
- References 183
Salivary Gland Neoplasms in Children and Adolescents 185
- Abstract 185
- Introduction 185
- Epithelial Salivary Gland Neoplasms (ESGN) 187
- Presentation 187
- Differential Diagnosis and Investigation 187
- Staging of Salivary Gland Malignancies 188
- Treatment 188
- Postoperative Radiotherapy 189
- Recurrence 189
- References 190
- Outcome 190
Distant Metastases and Palliative Care 192
- Abstract 192
- Background 192
- Treatment Options 195
- Conclusion 197
- References 197
Quality of Life after Salivary Gland Surgery 199
- Abstract 199
- Introduction 199
- Sensation 200
- Frey’s Syndrome 201
- Incisions 202
- Facial Paralysis 204
- Salivary Gland Carcinoma 205
- References 206
- Conclusion 206
Salivary Gland Neoplasms: Future Perspectives 208
Author Index 210
Subject Index 211
Cover 216

Pokaż więcej

Opis

Spis treści

Recenzje (0)