Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics.

New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields.

• Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine
• Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology
• Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

• Front Cover 2
• Principles of Translational Science in Medicine 5
• Copyright Page 6
• Contents 7
• List of contributors 15
• I. Introduction 19
  • 1 Introduction and definitions 21
    • What is translational medicine? 21
    • Primary translation versus secondary translation 22
    • The history of translational medicine, obstacles, and remits 23
    • References 25
  • 2 Problems, challenges, and initiatives in translation 27
    • Attrition 27
    • What translational medicine can and cannot do 29