This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs.

Bisphosphonates in Bone Disease, Fourth Edition, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs.

• The revised fourth edition contains approximately 50% new material
• Includes information on all the latest drugs

• Front Cover 2
• Bisphosphonates in Bone Disease: From the Laboratory to the Patient 5
• Copyright Page 6
• Contents 7
• Preface 13
• Chapter 1. Bone and mineral metabolism 15
  • 1.1. Bone physiology 15
• Chapter 2. Bisphosphonates—preclinical 41
  • 2.1. Background to the pharmacological development 41
  • 2.2. Chemistry 44
  • 2.3. Actions 48
  • 2.4. Pharmacokinetics 70
  • 2.5. Animal toxicology 77
• Chapter 3. Bisphosphonates—clinical 81
  • 3.1. Introduction 81