The Alkaloids

Opis

The Alkaloids: Chemistry and Physiology, Volume II focuses on strychnine and morphine alkaloids.

This book discusses the elucidation of the structure of morphine, codeine, and thebaine; synthetic hydrophenanthrenes related to the morphine alkaloids; and stereochemistry of the morphine alkaloids and sinomenine. The elucidation of the constitution of sinomenine, biological effects of colchicine, chemistry of individual alkaloids, and alkaloids of gelsemium species are also elaborated. This text likewise covers the isolation of the alkaloids, phenanthrene nucleus of morphine, fission around the nitrogen atom, and synthetic hydrophenanthrenes related to the morphine alkaloids.

This volume is useful to chemists and researchers conducting work on alkaloid chemistry.

Spis treści

Front Cover 2
The Alkaloids: Chemistry and Physiology 5
Copyright Page 6
PREFACE 7
Table of Contents 9
Chapter VIII. PART(I) The Morphine Alkaloids 11
- I Introduction 12
- II. Elucidation of the Structure of Morphine, Codeine, and Thebaine 13
- III. The Reactions of Morphine, Codeine, and Related Products 48
- IV. The Reactions of Thebaine and Related Products 90
- V. Synthetic Hydrophenanthrenes Related to The Morphine Alkaloids 126
- VI. Table of Physical Constants 134
- REFERENCES 162
Chapter PART. VIII. (II) The Morphine Alkaloids 171
- I. Introduction 172

Front Cover 2
The Alkaloids: Chemistry and Physiology 5
Copyright Page 6
PREFACE 7
Table of Contents 9
Chapter VIII. PART(I) The Morphine Alkaloids 11
- I Introduction 12
- II. Elucidation of the Structure of Morphine, Codeine, and Thebaine 13
- III. The Reactions of Morphine, Codeine, and Related Products 48
- IV. The Reactions of Thebaine and Related Products 90
- V. Synthetic Hydrophenanthrenes Related to The Morphine Alkaloids 126
- VI. Table of Physical Constants 134
- REFERENCES 162
Chapter PART. VIII. (II) The Morphine Alkaloids 171
- I. Introduction 172
- II. The Reactions of Morphine, Codeine and Neopine 173
- III. Reactions of Thebaine and Related Products 177
- IV. The Stereochemistry of Morphine and Sinomenine 183
- V. Rearrangement and Elimination Reactions 201
- VI. The Synthesis of Related Products 215
- REFERENCES 228
CHAPTER IX. Sinomenine 231
- I. Physiological Action, Isolation and Color Reactions 231
- II. Elucidation of the Constitution of Sinomenine 235
- III. Reactions of Sinomenine and Related Products 242
- IV, Partial Synthesis of the Antipode of 1-Bromosinomeninone 257
- V. Table of Physical- Constants 259
- REFERENCES 270
CHAPTER X. Colchicine 273
- I. Chemistry of Colchicine 273
- II. Biological Effects of Colchicine 303
- REFERENCES 330
CHAPTER XI. Alkaloids of the Amaryllidaceae 343
- I. Occurrence and General History 343
- II. Chemistry of Individual Alkaloids 348
- REFERENCES 363
CHAPTER XII. Acridine Alkaloids 365
- I. Introduction 365
- II. Degradation 368
- III. Conclusion 379
- REFERENCES 380
CHAPTER XIII. The Indole Alkaloids 381
- II. The Simple Bases 383
- I. Introduction 383
- III. The Ergot Alkaloids 387
- IV. The Alkaloids of Peganum harmala L. 405
- V; Alkaloids of Evodia rutaecarpa 414
- VII. The Quebracho Alkaloids 434
- VIII. Alkaloids of Rauwolfia Species 436
- IX. Alkaloids of Gelsemium Species 442
- X. The Alkaloids of Calycanthaceae 446
- XI. Alkaloids of Calabar Bean 450
- XII. The Iboga Alkaloids 462
- XIII. Alkaloids of Alstonia Species 463
- XIV. Alkaloids of Geissospermum vellosii Allem. Diss 467
- XV. Quinamine and Cinchonamine 468
- XVI. C-Dihydrotoxiferine 473
- XVII. Table of Physical Constants 473
- REFERENCES 493
CHAPTER XIV. The Erythrina Alkaloids 511
- I. Introduction 511
- III. Isolation of the Alkaloids 512
- II. Distribution 512
- IV. The Free Alkaloids 514
- V. The Combined Alkaloids 518
- VI. The Liberated Alkaloids 518
- REFERENCES 522
CHAPTER XV. The Strychnos Alkaloids. Part II 525
- I. Introduction 525
- II. Elucidation of the Structure of Strychnine and Brucine 526
- III. Vomicine and Vomipyrine 539
- IV. The Structure and Stereochemistry of Strychnine 545
- V. Tables of Physical Constants 551
- REFERENCES 562
Author Index 565
Subject Index 590

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